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Transgenic zebrafish. The functions of MEK1 and MEK2 inside the Ras

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We suggest that these skin cells were experiencing hyper-proliferation due to MEK2 activation. This observation may be relevant to psoriasis but needs further investigation. Ras proto-oncogenes are central regulators activating intracellular Ras-Raf-MEK-ERK signaling pathway in tumorigenesis. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25957400 The zebrafish is increasingly Pyridoxol (hydrochloride);Vitamin B6 (hydrochloride)supplier employed as a vertebrate model for studying tumorigenesis and drug screening. A transgenic PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26795252 strategy is normally utilised for establishing a transgenic zebrafish.Transgenic zebrafish. The functions of MEK1 and MEK2 within the Ras/Raf/ Mek/Erk signaling pathway have been properly documented. Throughout epidermal neoplasia formation, MEK2 and MEK1 showed mainly comparable functions, but each had many differences. In zebrafish, the functions of MEK1 andFig. 6 Impact of MEK2S219D on cell proliferation was analyzed in COS-1 cells and in transgenic zebrafish. a The pcDNA3-MEK2S219D-GFP and pcDNA3-GFP (control) plasmids was transfected to COS-1 cells and evaluated the cell numbers by trypan blue assay from 1 to four days post-transfection. Outcomes represent the mean of 3 independent determinations. * p