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Three regulated pathways in male samples were vesicle-mediated transport (38 ), extracellular matrix

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BMC Genomics (2017) 18:Page 8 ofTable 3 Pathway enrichment analysis of PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28506461 up-regulated pathways in swiftlet salivary glandsAA versus Aerodramus species AA Number of pathways up-regulated 328 Top 3 regulated pathway - Translation factors (27.4 ) - mRNA processing (10.9 ) - Spliceosome (8.8 ) Aerodramus species 341 - mRNA processing (15.5 ) - Protein export (14.4 ) - Squamous cell TarBase (9.1 ) AFC versus AMC AFC Number of pathways up-regulated 152 Top 3 regulated pathway - PI3K-Akt signaling pathway (46 ) - Ribosome biogenesis in eukaryotes (12.5 ) - Cardiac muscle contraction (6.5 ) AMC 120 - Ras signalling pathway (38 ) - MAPK signalling pathway (29 ) - Proteasome (20 ) AFM versus AFC AFM Number of pathways up-regulated 34 Top 3 regulated pathway - Galactose metabolism (38 ) - Endocytosis (15 ) - Oxidative phosphorylation (15 ) AFC 7 - Mitochondrial fatty acid oxidation (43 ) - RNA transport (29 ) - Proteoglycan (29 ) Gender comparison AFC Female Number of pathways up-regulated 34 Top 3 regulated pathway -DNA repair (61 ) -Nt information. W.L., and Y.D. generated stable cell line Circadian clock (20 ) -Cell cycle (12 ) Male 25 -Mitochondrial protein (40 ) -Peptide hormone metabolism (23 ) -Muscle contraction (15 ) AFM Female Male Number of pathways up-regulated 0 15 Top 3 regulated pathway -NA -Transmembrane transport of small molecule (17.5 ) -Protein metabolism (5.8 ) -Signal transduction (5.1 ) AMC Female Number of pathways up-regulated 13 Top 3 regulated pathway -Organelle biogenesis and maintenance (23 ) -Muscle contraction (17 ) -Axon guidance (9 )Table 3 Pathway enrichment analysis of up-regulated pathways in swiftlet salivary glands (Continued)Male 5 -Vesicle-mediated transport (38 ) -Extracellular PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/27385778 matrix transport (29 ) -Signal transduction (23 ) AFC Aerodramus fuciphagus from cave AFM Aerodramus fuciphagus from man-made house AMC Aerodramus maximus from cave AA Apus affinis NA No regulated pathways with p-value PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28506461 up-regulated pathways in swiftlet salivary glandsAA versus Aerodramus species AA Number of pathways up-regulated 328 Top 3 regulated pathway - Translation factors (27.4 ) - mRNA processing (10.9 ) - Spliceosome (8.8 ) Aerodramus species 341 - mRNA processing (15.5 ) - Protein export (14.4 ) - Squamous cell TarBase (9.1 ) AFC versus AMC AFC Number of pathways up-regulated 152 Top 3 regulated pathway - PI3K-Akt signaling pathway (46 ) - Ribosome biogenesis in eukaryotes (12.5 ) - Cardiac muscle contraction (6.5 ) AMC 120 - Ras signalling pathway (38 ) - MAPK signalling pathway (29 ) - Proteasome (20 ) AFM versus AFC AFM Number of pathways up-regulated 34 Top 3 regulated pathway - Galactose metabolism (38 ) - Endocytosis (15 ) - Oxidative phosphorylation (15 ) AFC 7 - Mitochondrial fatty acid oxidation (43 ) - RNA transport (29 ) - Proteoglycan (29 ) Gender comparison AFC Female Number of pathways up-regulated 34 Top 3 regulated pathway -DNA repair (61 ) -Circadian clock (20 ) -Cell cycle (12 ) Male 25 -Mitochondrial protein (40 ) -Peptide hormone metabolism (23 ) -Muscle contraction (15 ) AFM Female Male Number of pathways up-regulated 0 15 Top 3 regulated pathway -NA -Transmembrane transport of small molecule (17.5 ) -Protein metabolism (5.8 ) -Signal transduction (5.1 ) AMC Female Number of pathways up-regulated 13 Top 3 regulated pathway -Organelle biogenesis and maintenance (23 ) -Muscle contraction (17 ) -Axon guidance (9 )Table 3 Pathway enrichment analysis of up-regulated pathways in swiftlet salivary glands (Continued)Male 5 -Vesicle-mediated transport (38 ) -Extracellular PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/27385778 matrix transport (29 ) -Signal transduction (23 ) AFC Aerodramus fuciphagus from cave AFM Aerodramus fuciphagus from man-made house AMC Aerodramus maximus from cave AA Apus affinis NA No regulated pathways with p-value