Newly regenerated immature granulation C29 Formula tissue that was noticed around the remnant of the collagen implant at 20 DPI, became mature as well as the remnants of collagen implant were absorbed and substituted by PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27107493 the newly regenerated aligned collagen fibers. At 60 DPI the immature and mature tendinous tissue that was observed at 40 DPI, have been fully homogenized and matured so that all parts with the injured area was filled using the aligned and matured regenerated tendon (Figure 6I). At 120 DPI, the collagen fibers had been denser and compact obtaining fewer fibroblasts that were mainly matured. The little blood vessels were not evident within the injured location and all components in the regenerated tissue showed the characteristics in the tendon (Figure 7B). At this stage the control tendons showed fatty degeneration, muscle fibrosis, peri-tendinous adhesions and also the newly regenerated tissue had qualities comparable to loose areolar connective tissue (Figure 7A,D). No tendinous nature was evident within the injured region with the manage lesions.Newly regenerated immature granulation tissue that was seen about the remnant of the collagen implant at 20 DPI, became mature and also the remnants of collagen implant were absorbed and substituted by PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27107493 the newly regenerated aligned collagen fibers. No characteristic inflammation was evident inMeimandi-Parizi et al. Journal of Biomedical Science 2013, 20:28 http://www.jbiomedsci.com/content/20/1/Page 15 ofFigure 6 Histopathological findings (Portion 1), mechanism of host-graft interaction (Results section: Histopathological findings). At 7 DPI, the inflammatory cells infiltrated inside the implant (A). Three parts are noticed. The path with the healing response is shown (arrows). Granulation tissue is formed around the implant. The inflammatory cells are in the middle aspect i.e. in the necrotic region. The third portion may be the collagen implant and no cell is seen within this location (A). At ten DPI, the inflammatory cells are distributed all more than the implant (B). At 15 DPI, unique responses to implant are observed (C). Inside the left side, the implant (CI) is seen with no inflammatory response about it. Around the right side, edema (E), neutrophil accumulation (N) and chronic inflammation is observed (C). At 20 DPI (D E), the remnants of your implant are present together with the lied tenoblasts around them. The granulation tissue is formed about these remnants. Inflammation was subsided as well as the remnants acted as scaffolds and aligned the new tissue (D E). At 30 DPI, two parts in the injured tendons may very well be seen (F G). No remnant of the implant was observed and the newly regenerated immature tendon at 20 DPI (E) was matured at this stage (F G). The remnants from the collagen implant that have been observed at 20 DPI, have been absorbed and substituted by the newly regenerated tissue at this stage (F G). At 40 DPI, this description is additional likely to be characteristic along with the newly regenerated tissue at the center on the field is aligned along the direction on the previously regenerated extra mature tendinous tissue at the corners (H). At 60 DPI, all the collagen fibers are mature in addition to a homogenous PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25609842 tendon is formed (I).